Why the study?
Excessive vasoconstriction during mental stress may link acute psychological stress to adverse cardiac events, but whether excessive digital vasoconstriction predicts adverse outcomes in CAD was unclear.
Does excessive digital vasoconstriction during acute mental stress predict adverse cardiovascular outcomes in patients with coronary artery disease?
Does excessive digital vasoconstriction during acute mental stress predict adverse cardiovascular outcomes in patients with coronary artery disease?
Greater peripheral vasoconstriction during mental stress, indicated by a low sPAT ratio, is associated with a significantly higher risk of adverse cardiovascular outcomes in patients with coronary artery disease.
May support refined risk stratification in CAD; leaves open whether mental stress reactivity is a modifiable target requiring prospective trials.
RATIONALE: Excessive vasoconstriction in response to mental stress may be a potential mechanism by which acute psychological stress leads to adverse cardiac events. OBJECTIVES: We investigated whether excessive digital vasoconstriction during acute mental stress predicts adverse cardiovascular outcomes among patients with coronary artery disease. METHODS AND RESULTS: =0.003). After adjusting for demographic and cardiovascular risk factors, medications, and rate-pressure product change during mental stress, those with low sPAT ratio were at significantly higher risk of adverse outcomes (subdistribution hazard ratio, 1.77 [95% CI, 1.12-2.80]). CONCLUSIONS: Greater peripheral vasoconstriction with mental stress, denoted by a low sPAT ratio, is associated with a higher risk of adverse cardiovascular outcomes in patients with coronary artery disease.
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Kim et al. (2019) studied this question.
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