What question did this study set out to answer?

To review the mechanisms underlying NF-κB activation and assess whether reactive oxygen species play a direct physiological role as oxidative stress sensors.

July 1, 1999The FASEB Journal

Is NF‐κB the sensor of oxidative stress?

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Authors

NLNanxin LiSichuan Agricultural University MKMichael KarinDiscovery Institute

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Implication

Review examines signal transduction mechanisms of NF-κB activation by reactive oxygen species in cellular pathways, highlighting uncertainties regarding its role as a direct oxidative stress sensor.

Key Points

To review the mechanisms underlying NF-κB activation and assess whether reactive oxygen species play a direct physiological role as oxidative stress sensors.
Synthesized molecular evidence on signal transduction cascades mediating NF-κB activation.
Evaluated responses across cellular stimuli, including pro-inflammatory cytokines, radiation exposure, and hydrogen peroxide.
NF-κB functions as a critical dimeric transcription factor governing genes responsible for immune and inflammatory responses following exposure to cytokines and oxidative stress.
While cytokine-induced signaling models illuminate potential activation cascades, the precise physiological requirement of reactive oxygen species in triggering NF-κB remains unproven.

Cite This Study

Li et al. (1999) studied this question.

synapsesocial.com/papers/69fd29cd807917f9cf08648e https://doi.org/10.1096/fasebj.13.10.1137

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Implication

Review examines signal transduction mechanisms of NF-κB activation by reactive oxygen species in cellular pathways, highlighting uncertainties regarding its role as a direct oxidative stress sensor.

Is NF‐κB the sensor of oxidative stress?

Discussion

Member takes

Implication

Key Points

Cite This Study

Is NF‐κB the sensor of oxidative stress?

Discussion

Member takes

Implication

Key Points

Cite This Study

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