Why the study?
Does left ventricular outflow tract obstruction affect cardiorespiratory responses and peripheral oxygen extraction during exercise in patients with hypertrophic cardiomyopathy?
Population
70 patients with hypertrophic cardiomyopathy, mean age 47±13, 55 male, and 28 normal volunteers.
Comparison
Cardiopulmonary exercise testing with… vs Normal volunteers and HCM patients without LVOTO
Design
Cohort
Authors
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LVOTO further impairs exercise cardiac reserve in HCM; hypothesis-generating, prospective trials needed before guiding management.
Does left ventricular outflow tract obstruction affect cardiorespiratory responses and peripheral oxygen extraction during exercise in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, cardiac reserve is significantly reduced due to a failure of stroke volume augmentation during exercise, an abnormality that is further exacerbated by left ventricular outflow tract obstruction.
Critoph et al. (2014) studied this question.
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