April 17, 2008Medicine & Science in Sports & Exercise
Ventilatory Efficiency and Resting Hemodynamics in Hypertrophic Cardiomyopathy
Why the study?
Can cardiopulmonary exercise testing (CPX) variables accurately reflect resting hemodynamics in patients with nonobstructive hypertrophic cardiomyopathy?
Population
83 subjects with nonobstructive hypertrophic cardiomyopathy, mean age 38 +/- 10 years, 51 male/32 female…
Comparison
Cardiopulmonary exercise testing to measure peak… vs Right heart catheterization to measure resting…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May inform noninvasive hemodynamic assessment in nonobstructive HCM; hypothesis-generating and requires prospective validation.
Structured PICO
Can cardiopulmonary exercise testing (CPX) variables accurately reflect resting hemodynamics in patients with nonobstructive hypertrophic cardiomyopathy?
P
Population
83 subjects with nonobstructive hypertrophic cardiomyopathy (NHCM), mean age 38 +/- 10 years, 51 male/32 female, NYHA I-III (mean 1.7).
I
Intervention
Cardiopulmonary exercise testing (CPX) to measure peak oxygen consumption (VO2) and minute ventilation/carbon dioxide ratio (VE/VCO2)
C
Comparator
Right heart catheterization to measure resting hemodynamics (PASP, PADP, MPAP, PCWP)
O
Outcome
Correlation and diagnostic accuracy of CPX variables to reflect resting hemodynamicssurrogate
Cardiopulmonary exercise testing, specifically a VE/VCO2 >35.5, can accurately identify abnormal resting hemodynamics in patients with nonobstructive hypertrophic cardiomyopathy.
Cite This Study
Arena et al. (2008) studied this question.