Why the study?
Does transgenic expression of hGLUT4 to normalize cardiac metabolism improve contractile function in diabetic db/db mice?
Population
Control db/+ mice, diabetic db/db mice at 6 and 12 weeks of age, and transgenic db/db-human glucose…
Comparison
Transgenic expression of human glucose… vs Diabetic db/db mice without the hGLUT4 transgene…
Design
Preclinical
Follow-up
Assessed at 6 and 12 weeks of age
Authors
Loading...
hGLUT4-mediated metabolic normalization restores function in diabetic mice; leaves open translation to human diabetic cardiomyopathy.
Does transgenic expression of hGLUT4 to normalize cardiac metabolism improve contractile function in diabetic db/db mice?
Altered cardiac metabolism contributes to contractile dysfunction in diabetic cardiomyopathy, which can be reversed by normalizing metabolism via hGLUT4 expression.
Semeniuk et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: