Why the study?
Does troglitazone improve left ventricular diastolic dynamics in a spontaneous diabetic rat model?
Population
40 rats (20 spontaneous diabetic [DM] rats and 20 age-matched nonDM rats) at 5 weeks of age.
Comparison
Troglitazone as a 0.2% food admixture for 10… vs Untreated DM and nonDM rats.
Design
Preclinical
Follow-up
10 weeks
Authors
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Hypothesis-generating for troglitazone in diabetic diastolic dysfunction; leaves open translation to human HFpEF.
Does troglitazone improve left ventricular diastolic dynamics in a spontaneous diabetic rat model?
Troglitazone improves left ventricular diastolic dynamics in a diabetic rat model at the prediabetic stage.
Yao et al. (2001) studied this question.
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