March 1, 1999Diabetes

Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts.

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Why the study?

Does troglitazone have direct cardiac hemodynamic effects in isolated perfused rat hearts?

Population

Isolated perfused rat hearts (5 groups)

Design

Preclinical

Follow-up

1 min after administration

Authors

MSM ShimoyamaSt George's, University of London KOKenji OginoTokyo University of Agriculture and Technology YTYoshihito TanakaJohnson & Johnson (Israel)

Discussion

Member takes

Implication

Suggests direct effects in diabetic rat hearts; hypothesis-generating and should not change practice without human trials.

Structured PICO

Does troglitazone have direct cardiac hemodynamic effects in isolated perfused rat hearts?

Population

Isolated perfused rat hearts (5 groups)

Intervention

Troglitazone (0.2, 0.5, and 1.0 micromol) administered by bolus injection

Outcome

Peak isovolumetric left ventricular pressure (LVPmax), peak rate of rise of LVP (dP/dt(max)), peak rate of fall of LVP (dP/dt(min)), heart rate (HR), and coronary perfusion pressure (CPP)surrogate

Troglitazone exerts direct positive inotropic, positive lusitropic, negative chronotropic, and coronary vasodilating effects in isolated rat hearts, independent of adrenergic or calcium channel pathways.

Cite This Study

Shimoyama et al. (1999) studied this question.

synapsesocial.com/papers/6a8cf91b1f5551fff22f058a https://doi.org/10.2337/diabetes.48.3.609

View Full Paper

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Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider