Key result
Troglitazone caused a dose-dependent, biphasic, endothelium-independent dilation in afferent arterioles (28% increase at 20 min, P<0.01) and monophasic dilation in efferent arterioles.
Population
Rabbit glomerular afferent and efferent arterioles microdissected from the superficial cortex
Design
Preclinical
Follow-up
up to 120 minutes
Authors
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In vitro arteriolar effects require in vivo confirmation; leaves open clinical relevance for thiazolidinedione renal hemodynamics.
p-value: p=<0.01
Troglitazone exhibits biphasic endothelium-independent vasodilation in afferent arterioles and monophasic dilation in efferent arterioles, potentially contributing to its blood pressure-lowering and renoprotective effects.
Arima et al. (2002) studied this question. Troglitazone vs. Baseline (preconstricted arterioles) was evaluated on Arteriolar diameter change (p=<0.01). Troglitazone caused a dose-dependent, biphasic, endothelium-independent dilation in afferent arterioles (28% increase at 20 min, P<0.01) and monophasic dilation in efferent arterioles.
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