Why the study?
Does troglitazone stimulate basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules?
Population
Rabbit proximal straight tubule perfused in vitro
Comparison
Troglitazone (5 to 50 µM in the bath) vs Absence of troglitazone
Design
Preclinical
Authors
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May explain troglitazone-associated edema via proximal tubule HCO3− transport; leaves open human relevance and clinical translation.
Does troglitazone stimulate basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules?
Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules, providing a potential mechanism for the edema formation associated with its use.
Muto et al. (2001) studied this question.
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