December 1, 1998Circulation

Mechanisms of Vasorelaxation Induced by Troglitazone, a Novel Antidiabetic Drug, in the Porcine Coronary Artery

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Population

fura 2-loaded medial strips of porcine coronary artery

Design

Preclinical

Authors

JKJunya KawasakiKumamoto University KHKatsuya HiranoKagawa University JNJunji NishimuraFukuoka Institute of Technology

Discussion

Member takes

Implication

Hypothesis-generating for coronary relaxation mechanisms; human studies needed before any clinical consideration.

Structured PICO

Population

fura 2-loaded medial strips of porcine coronary artery

Intervention

Troglitazone (TRO)

Outcome

cytosolic Ca2+ concentrations ([Ca2+]i) and contractionssurrogate

Troglitazone relaxes coronary arteries by decreasing cytosolic calcium and calcium sensitivity, primarily by inhibiting receptor-operated calcium influx.

Cite This Study

Kawasaki et al. (1998) studied this question.

synapsesocial.com/papers/6a870ee2b712452940cbb54e https://doi.org/10.1161/01.cir.98.22.2446

View Full Paper

Ask AI

Bookmark

Mechanisms of Vasorelaxation Induced by Troglitazone, a Novel Antidiabetic Drug, in the Porcine Coronary Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of Vasorelaxation Induced by Troglitazone, a Novel Antidiabetic Drug, in the Porcine Coronary Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider