A Core Outcome Set for Adult General ICU Patients

Maj‐Brit Nørregaard Kjær; Camilla Rahbek Lysholm Bruun; Anders Granholm; Morten Hylander Møller; Bodil Steen Rasmussen; Camilla Bekker Mortensen; Lone Musaeus Poulsen; Thomas Strøm; Eva Lærkner; Anne Craveiro Brøchner; Trine Haberlandt; Anne‐Marie Gellert Bunzel; Louise Stenbryggen Herløv; Anna Holm; Praleene Sivapalan; Stine Estrup; Maria Cronhjort; Anna Schandl; Jon Henrik Laake; Kristin Hofsø; Fredrike Blokzijl; Frederik Keus; Carmen A. Pfortmueller; Marlies Ostermann; Jade Cole; Matt P. Wise; Wojciech Szczeklik; Anna Włudarczyk; Tomas Jovaiša; Maurizio Cecconi; Martin I. Sigurðsson; Marek Nalos; Johanna Hästbacka; Marja Mäkinen; Naomi Hammond; Edward Litton; Kimberley Haines; Sheila Nainan Myatra; Bharath Kumar Tirupakuzhi Vijayaraghavan; Kavita Yadav; Vivekanand Jha; Balasubramanian Venkatesh; Ingrid Egerod; Anders Perner; Marie Oxenbøll Collet

doi:10.1097/ccm.0000000000006556

January 6, 2025Critical Care MedicineOpen Access

A Core Outcome Set for Adult General ICU Patients

View Full Paper

Ask AI

Bookmark

Share

Key Points

To develop and internationally validate a core outcome set for clinical trials involving adult general ICU patients.
Followed Core Outcome Measures in Effectiveness Trials (COMET) guidelines using a modified Delphi consensus process, literature review, and semi-structured interviews (n=82).
Administered a three-round Delphi survey initially engaging 264 participants (ICU survivors, family members, clinicians, and researchers) across five Danish panels.
Conducted international validation and refinement across 17 research panels in 13 additional countries spanning Europe, Australasia, and India (n=217 panel members).
Evaluated 329 candidate outcomes from the literature and included 50 in the Delphi survey, which achieved completion rates of 94% (249/264) in round one and 82% (202/249) in round three.
Established a final internationally validated core outcome set comprising six outcomes: survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Modified Delphi consensus study establishes a six-domain core outcome set for adult general intensive care patients, facilitating harmonized reporting across clinical trials.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kjær et al. (2025) studied this question.

synapsesocial.com/papers/69fd34d554949f8cfd5d1750 https://doi.org/10.1097/ccm.0000000000006556

View Full Paper

Ask AI

Bookmark

Share

A Core Outcome Set for Adult General ICU Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

A Core Outcome Set for Adult General ICU Patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading