Population
Isolated working rat heart
Comparison
Improved perfusion system allowing… vs Previous preparations with subphysiological…
Design
Preclinical
Follow-up
nearly 2 h
Authors
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May necessitate reevaluation of prior subphysiological cardiac metabolism data; leaves open translation to human models.
An improved isolated working rat heart perfusion system demonstrates that near-physiological workloads significantly alter cardiac metabolism compared to subphysiological models, highlighting the importance of physiological workload in cardiac metabolic studies.
Taegtmeyer et al. (1980) studied this question.
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