Why the study?
What is the prevalence and characteristics of familial AVNRT among patients undergoing radiofrequency ablation?
What is the prevalence and characteristics of familial AVNRT among patients undergoing radiofrequency ablation?
Familial AVNRT is more common than previously thought, suggesting a genetic component with likely autosomal dominant inheritance and incomplete penetrance.
Familial AVNRT may warrant targeted history-taking; leaves open whether inheritance patterns should guide screening or ablation decisions.
BACKGROUND: Atrioventricular nodal reentrant tachycardia (AVNRT) is considered a sporadic disease occurring in ≈22.5 cases per 10 000 in the general population. We define the prevalence and characteristics of familial AVNRT among patients who underwent radiofrequency ablation. METHODS AND The male/female ratio was similar, with female predominance. The supraventricular tachycardia mechanism was typical slow/fast reentry in most cases in both groups. The most common familial relationship in our 24 families included a parent and a child in 67% of cases and less often 2 siblings (29%). CONCLUSIONS: Familial AVNRT prevalence is higher than previously believed suggesting that this arrhythmia may have a genetic component. Autosomal dominance with incomplete penetrance is the most likely mode of inheritance.
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Michowitz et al. (2017) studied this question.
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