Skin Sympathetic Nerve Activity After Pulsed Field Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: The NEU-PFA Study

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  Figure.. Serial skin sympathetic nerve activity (SKNA) and heart rate after pulsed field ablation with only pulmonary vein isolation. A, Median SKNA values from the arm and chest are shown at baseline and during follow-up after ablation. Error bars indicate interquartile ranges (Q1–Q3). The shaded band and dashed line represent the baseline interquartile range and median, respectively. P values shown in A are nominal Wilcoxon signed-rank tests vs baseline; significance was interpreted after Holm adjustment for repeated follow-up comparisons within each channel. No significant sustained or multiplicity-adjusted change in SKNA was observed during follow-up. B, Median heart rate values are shown at baseline and during follow-up after ablation. Error bars indicate interquartile ranges. P values indicate paired comparisons vs baseline using the Wilcoxon signed-rank test among patients with paired baseline and follow-up heart-rate data. Heart rate did not significantly differ from baseline at any follow-up time point.