What question did this study set out to answer?

Evaluate the efficacy of the neutrophil-to-lymphocyte ratio (NLR) as a clinical predictor of antibiotic treatment response and mortality in ICU patients with sepsis and septic shock.

August 15, 2019TURKISH JOURNAL OF MEDICAL SCIENCESOpen Access

Neutrophil to lymphocyte ratio as a predictor of treatment response and mortality in septic shock patients in the intensive care unit

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RSRabıa SariChest Diseases Hospital ZKZühal KarakurtUniversity of Health Science MAMustafa AyAntalya Eğitim ve Araştırma Hastanesi

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Implication

Retrospective cross-sectional study reveals that elevated day-three neutrophil to lymphocyte ratios predict mortality in septic shock, highlighting its utility in guiding antibiotic adjustments.

Key Points

Evaluate the efficacy of the neutrophil-to-lymphocyte ratio (NLR) as a clinical predictor of antibiotic treatment response and mortality in ICU patients with sepsis and septic shock.
Conducted a retrospective cross-sectional analysis of 591 ICU patients (65% male) categorized by septic shock status on day 1 and subsequent survival.
Recorded NLR, C-reactive protein (CRP), APACHE II, and SOFA scores on days 1, 3, and the final ICU day, evaluating mortality discrimination using receiver operating characteristic (ROC) curves.
On day 3 of antibiotic therapy, NLR was elevated in nonresponsive patients (11.8) compared to partially responsive (11.0) and responsive patients (8.5).
An NLR ≥ 15 on day 3 predicted significantly increased mortality (OR 6.96, 95% CI: 1.4–34.1, P < 0.017).
Predictive accuracy for mortality progressively increased from day 1 to the final ICU day for both NLR (AUC: 0.52 to 0.78) and CRP (AUC: 0.56 to 0.78).

Cite This Study

Sari et al. (2019) studied this question.

synapsesocial.com/papers/69fd54f1ea4a61241c5d1b75 https://doi.org/10.3906/sag-1901-105

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Implication

Retrospective cross-sectional study reveals that elevated day-three neutrophil to lymphocyte ratios predict mortality in septic shock, highlighting its utility in guiding antibiotic adjustments.

Neutrophil to lymphocyte ratio as a predictor of treatment response and mortality in septic shock patients in the intensive care unit

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Cite This Study

Neutrophil to lymphocyte ratio as a predictor of treatment response and mortality in septic shock patients in the intensive care unit

Discussion

Member takes

Implication

Key Points

Cite This Study

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