Why the study?
Does estrogen or progestogen treatment alter the morphological and chemical response of the aortic wall to hypertension in male rats?
Population
Male rats with hypertension induced by clipping the renal artery
Comparison
Estrogen treatment or progestogen treatment vs Untreated hypertensive rats and normotensive…
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
May support estrogen protection against aortic remodeling in hypertensive rats; hypothesis-generating and should not yet inform clinical practice.
Does estrogen or progestogen treatment alter the morphological and chemical response of the aortic wall to hypertension in male rats?
Estrogen treatment inhibits hypertension-induced morphological and chemical changes in the aortic wall of male rats, suggesting a protective effect against vascular remodeling.
Harvey Wolinsky (1972) studied this question.