January 22, 2002Circulation
TIMI Myocardial Perfusion Grade and ST Segment Resolution: Association With Infarct Size as Assessed by Single Photon Emission Computed Tomography Imaging
Why the study?
Are early 90-minute TIMI myocardial perfusion grade and ST segment resolution associated with infarct size assessed by SPECT in patients with acute myocardial infarction after thrombolysis?
Population
Patients with acute myocardial infarction treated with thrombolysis in the LIMIT AMI trial.
Comparison
Early 90-minute TIMI myocardial perfusion grade… vs Comparison between different grades
Design
Cohort
Authors
Discussion
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Member takes
Implication
These markers may aid post-thrombolysis risk stratification; leaves open whether targeting them reduces infarct size.
Structured PICO
Are early 90-minute TIMI myocardial perfusion grade and ST segment resolution associated with infarct size assessed by SPECT in patients with acute myocardial infarction after thrombolysis?
P
Population
Patients with acute myocardial infarction treated with thrombolysis (lytic monotherapy or lytic plus rhuMAb CD18) in the LIMIT AMI trial (n=242 for ST resolution, n=221 for TMPG).
I
Intervention
Early 90-minute TIMI myocardial perfusion grade (TMPG) and ST segment resolution assessment
C
Comparator
Comparison between different grades (TMPG 0 or 1 vs TMPG 2 or 3; no or incomplete ST resolution vs complete ST resolution)
O
Outcome
Infarct size assessed by SPECT Technetium-99m Sestamibi (percentage of the left ventricle with no Sestamibi uptake)surrogate
Early restoration of tissue-level perfusion, as measured by TMPG and ST-segment resolution, is associated with reduced subsequent infarct size in patients with acute myocardial infarction.
Cite This Study
Angeja et al. (2002) studied this question.