What question did this study set out to answer?

To characterize the histopathological features and anatomical distribution of Giardia trophozoites in the upper and lower gastrointestinal tract.

Giardiasis: A Histologic Analysis of 567 Cases

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Retrospective study reveals normal mucosal histology in most giardiasis cases, highlighting the necessity of direct parasite detection during biopsy.

To characterize the histopathological features and anatomical distribution of Giardia trophozoites in the upper and lower gastrointestinal tract.
Retrospective histologic analysis of N=567 consecutive clinical cases of giardiasis evaluated via endoscopic gastrointestinal mucosal biopsies between 1988 and 1994.
Trophozoites were detected in duodenal (82.5%), ileal (12.1%), gastric antral (8.7%), jejunal (2.1%), and colonic (0.4%) mucosa.
Duodenal mucosal architecture was entirely normal by light microscopy in 96.3% of cases (462/480), with only 3.7% (18 cases) showing mild villous blunting and lamina propria inflammation.
In 252 patients with gastric biopsies, diagnoses included Helicobacter pylori-associated gastritis (57.8%), reactive gastritis (10.3%), normal mucosa (12.9%), and chronic atrophic gastritis of the body (2.9%).

Oberhuber et al. (1997) studied this question.

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Retrospective study reveals normal mucosal histology in most giardiasis cases, highlighting the necessity of direct parasite detection during biopsy.