What question did this study set out to answer?

To provide evidence-based recommendations on germline mutation testing and related genetic counseling for individuals diagnosed with breast cancer.

January 4, 2024Journal of Clinical Oncology

Germline Testing in Patients With Breast Cancer: ASCO–Society of Surgical Oncology Guideline

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Authors

IBIsabelle BedrosianThe University of Texas MD Anderson Cancer Center MSMark R. SomerfieldAmerican Society of Clinical Oncology MAMaria Isabel AchatzHospital Sírio-Libanês

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Implication

Clinical practice guideline reports recommendations for germline genetic testing in patients with breast cancer, highlighting risk-stratified variant interpretation and counseling.

Key Points

To provide evidence-based recommendations on germline mutation testing and related genetic counseling for individuals diagnosed with breast cancer.
An expert ASCO–Society of Surgical Oncology panel conducted a systematic review combined with a formal consensus development process.
Reviewed 47 articles evaluating germline mutation testing criteria and 18 articles addressing genetic counseling strategies.
Germline testing is recommended for individuals with supportive family histories, and testing for moderate-penetrance genes may be offered to clarify personal and familial risks.
Patients with identified pathogenic variants should receive tailored post-test counseling, whereas variants of uncertain significance must not alter clinical care.
Referral to clinical cancer genetics providers is recommended to support test selection, variant reclassification follow-up, and management of patients with significant family histories.

Cite This Study

Bedrosian et al. (2024) studied this question.

synapsesocial.com/papers/69fd6274f9b1bbfa2c270ec7 https://doi.org/10.1200/jco.23.02225

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Implication

Clinical practice guideline reports recommendations for germline genetic testing in patients with breast cancer, highlighting risk-stratified variant interpretation and counseling.

Germline Testing in Patients With Breast Cancer: ASCO–Society of Surgical Oncology Guideline

Discussion

Member takes

Implication

Key Points

Cite This Study

Germline Testing in Patients With Breast Cancer: ASCO–Society of Surgical Oncology Guideline

Discussion

Member takes

Implication

Key Points

Cite This Study

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