Why the study?
It remains controversial whether existing pharmacologic and psychological interventions are effective for treating depression in patients with chronic kidney disease and end-stage kidney disease.
Do pharmacologic and psychological interventions improve depressive symptoms in patients with chronic kidney disease and end-stage kidney disease?
Do pharmacologic and psychological interventions improve depressive symptoms in patients with chronic kidney disease and end-stage kidney disease?
While data do not support unlimited SSRI use in CKD/ESRD patients due to tolerability issues, a cautious trial of sertraline or use of CBT may be reasonable for treating major depressive disorder.
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Cautions against routine sertraline in nondialysis CKD; leaves open CBT role and optimized strategies in ESRD.
Gregg et al. (2020) studied this question.
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