Key result
Sertraline treatment in hemodialysis patients with depression resulted in lower trial completion compared to placebo (8/15 vs 13/15; P=0.05) and no difference in depression score improvement.
Why the study?
Does sertraline improve depression scores in patients with major depressive disorder undergoing hemodialysis?
RCT (n=30)
double-blind
randomized
Yes
Does sertraline improve depression scores in patients with major depressive disorder undergoing hemodialysis?
Absolute Event Rate: 53.3% vs 86.7%
p-value: p=0.05
In a small feasibility trial of hemodialysis patients with major depressive disorder, sertraline did not show benefit over placebo and was associated with higher dropout rates due to adverse events.
No takes yet. Share an insight, caveat, or question.
Caution advised against sertraline for depression in hemodialysis; this RCT leaves open need for larger trials of alternatives.
Friedli et al. (2017) conducted an RCT in Major depressive disorder (n=30). Sertraline vs. Placebo was evaluated on Trial completion (p=0.05). Sertraline treatment in hemodialysis patients with depression resulted in lower trial completion compared to placebo (8/15 vs 13/15; P=0.05) and no difference in depression score improvement.
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