Why the study?
Does sertraline improve depressive symptoms in patients with non-dialysis-dependent CKD and MDD?
Population
201 patients with stage 3, 4, or 5 non-dialysis-dependent chronic kidney disease and major depressive…
Comparison
Sertraline for 12 weeks at an initial dose of 50… vs Matching placebo after a 1-week placebo run-in.
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
12 weeks
Authors
Loading...
Sertraline offers no depressive symptom benefit in non-dialysis CKD with MDD; challenges routine use and supports trials of alternative therapies.
Does sertraline improve depressive symptoms in patients with non-dialysis-dependent CKD and MDD?
Sertraline did not significantly improve depressive symptoms compared with placebo in patients with non-dialysis-dependent CKD and MDD, but it did increase gastrointestinal adverse events.
Hedayati et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: