Research progress on the correlation between gut microbiota and the occurrence of hyperuricemia

Hyperuricemia is a metabolic disorder caused by excessive uric acid production or reduced uric acid excretion in the body. Approximately 30% of the uric acid in the human body is excreted through the intestines. As a vital component of the intestine, the gut microbiota influences host uric acid levels through multiple mechanisms and pathways, including purine metabolism, short chain fatty acid production, and intestinal barrier function. Additionally, hyperuricemia can also affect the distribution of gut microbiota, and a dysbiosis in this distribution may further trigger inflammation. This paper reviews the correlation between gut microbiota and the occurrence of hyperuricemia, providing a reference for treating hyperuricemia through the gut microbiota.