Retrospective analysis shows higher uric acid levels reduce severe cerebral edema risk in LVO-AIS patients, suggesting potential neuroprotective effects.
Key Points
This study investigates the relationship between serum uric acid levels and the risk of moderate-to-severe cerebral edema in large-vessel occlusion patients post-mechanical thrombectomy.
Performed a retrospective analysis of 272 patients with anterior circulation LVO-AIS post-thrombectomy.
Categorized patients into mild and moderate-to-severe cerebral edema groups.
Utilized multivariate logistic regression to assess associations between uric acid levels and cerebral edema risk.
Patients in the no-to-mild cerebral edema group had significantly higher uric acid levels (median 310.0 vs. 302.0 μmol/L; p < 0.05).
Higher uric acid levels were inversely correlated with moderate-to-severe cerebral edema risk (adjusted OR: 0.74; 95% CI: 0.56–0.99; p = 0.044).
Among patients with glucose < 7.5 mmol/L, those with uric acid ≥ 360 μmol/L showed a 76% lower risk of moderate-to-severe cerebral edema (aOR: 0.24; 95% CI: 0.09–0.69; p = 0.033).