What question did this study set out to answer?

This research evaluates post-transplant cytokine release syndrome (CRS) in allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy).

May 8, 2026Frontiers in ImmunologyOpen Access

Cytokine release syndrome after allogeneic hematopoietic stem cell transplantation using posttransplant cyclophosphamide: current understanding and management

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Authors

JWJiasheng WangThe Ohio State University KAKirti AroraCleveland Clinic MLMarcos de LimaThe Ohio State University

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Implication

Randomized trial examines cytokine release syndrome after hematopoietic stem cell transplantation, suggesting improved management strategies.

Key Points

This research evaluates post-transplant cytokine release syndrome (CRS) in allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy).
Analyzed the incidence and risk factors of CRS in alloHCT with PTCy across various donor types.
Investigated effectiveness of tocilizumab and prophylactic strategies in managing CRS and its association with GVHD.
Assessed the complications related to neurotoxicity in patients experiencing severe CRS.
CRS incidence varies: approximately 10% in matched sibling, 20-75% in matched unrelated, and 80-90% in haploidentical donors.
Severe CRS linked to delayed engraftment, increased acute GVHD, and decreased chronic GVHD.
Tocilizumab showed effectiveness in treating CRS, but its influence on GVHD risk requires additional research.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7cd4bfa21ec5bbf05c2d https://doi.org/10.3389/fimmu.2026.1642583

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Implication

Randomized trial examines cytokine release syndrome after hematopoietic stem cell transplantation, suggesting improved management strategies.

Cytokine release syndrome after allogeneic hematopoietic stem cell transplantation using posttransplant cyclophosphamide: current understanding and management

Discussion

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Implication

Key Points

Cite This Study

Cytokine release syndrome after allogeneic hematopoietic stem cell transplantation using posttransplant cyclophosphamide: current understanding and management

Discussion

Member takes

Implication

Key Points

Cite This Study

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