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May 8, 2026Frontiers in ImmunologyOpen Access

Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic

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Authors

SMSiyao MaXWX WangMLM D Li

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Overview

Narrative review explores how citrus flavonoids impact lung cancer microenvironment, suggesting new therapeutic avenues.

Key Points

  • To explore how citrus flavonoids affect the tumor microenvironment in lung cancer and highlight their therapeutic potential.
  • Narrative review of literature from databases including PubMed and Web of Science from 2016 to 2026.
  • Analysis of the molecular mechanisms by which flavonoids from Citri Reticulatae Pericarpium affect lung cancer.
  • Discussion of emerging targets and barriers to clinical translation.
  • Citrus flavonoids modulate oxidative stress and inflammation in the tumor microenvironment.
  • Regulation of lipid metabolism and induction of pyroptosis reported in lung cancer models.
  • Identification of cGAS-STING pathway as a promising target for enhancing immunotherapy efficacy.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/69fd7d4abfa21ec5bbf05cb6https://doi.org/10.3389/fimmu.2026.1806088
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