Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population

Salma Kabbashi; Ndonwi Elvis Ngwa; Haly Holmes; Yvonne Prince; Manogari Chetty

doi:10.1016/j.identj.2026.109606

May 4, 2026International Dental JournalOpen Access

Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study investigates the association between genetic variants and susceptibility to periodontitis in a South African population.
Observational case-control design involving 150 participants from South Africa.
Saliva samples were genotyped using the OpenArray QuantStudio 12K Flex qPCR System.
Chi-square tests and logistic regression adjusted for age, gender, and smoking were used for analysis.
OPG + 1181 CG, RANKL RL2 AG, and IL-17A + 197 GG genotypes indicated higher plaque scores.
TNF-α -238 GG genotype significantly reduced disease risk (OR = 0.157, 95% CI: 0.039-0.638, P = .010).
IL-1B -511 GG genotype associated with lower disease risk (adjusted OR = 0.216, 95% CI: 0.054-0.867, P = .031).

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Observational case-control study finds genetic associations with periodontitis in a South African cohort, suggesting population-specific risk factors.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kabbashi et al. (2026) studied this question.

synapsesocial.com/papers/69fd7d4abfa21ec5bbf05d7f https://doi.org/10.1016/j.identj.2026.109606

View Full Paper

Ask AI

Bookmark

Share

Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading