Development and Psychometric Evaluation of the Liver Disease Stigma Scale (LDSS)

May 1, 2026JHEP ReportsOpen Access

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Key Points

The aim is to develop and psychometrically evaluate the Liver Disease Stigma Scale (LDSS) for measuring stigma in chronic liver disease patients.
Conducted a cross-sectional study of 211 patients from hepatology services, categorized as alcohol-associated liver disease (ALD) or non-ALD.
Assessed stigma using the LDSS and evaluated psychometric properties including exploratory factor analysis (EFA) and internal consistency (Cronbach's alpha).
Evaluated convergent validity with the Substance Use Stigma Mechanisms Scale and mental health symptoms using statistical tests.
Five-factor structure of LDSS accounted for 73.7% of variance with excellent subscale reliability (0.90-0.97).
Demonstrated strong convergent validity with SU-SMS subscales (correlation r = 0.43-0.80).
Participants with ALD had significantly higher stigma scores (internalized stigma: 2.34 vs 1.50, p < 0.001, d = 0.85).

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Cross-sectional study evaluates liver disease stigma in patients, highlighting implications for care.

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Zhang et al. (2026) studied this question.

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