Theoretical analysis evaluates n-FABS assay performance in drug discovery, suggesting cost-effective applications.
values for different inhibitors covering the range from nM to hundreds of μM were determined. The limitations and strengths of this n-FABS assay are evaluated theoretically in depth. Based on these insights, optimized assays with fluorinated substrates can be implemented, which provide an ideal opportunity for efficient and cost-effective functional assays on benchtop NMR instruments.
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Jordan et al. (2026) studied this question.
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