What question did this study set out to answer?

The aim is to develop a low-cost solution for collecting ultrathin sections for large-volume electron microscopy.

May 8, 2026Cell Reports MethodsOpen Access

DRIFT-EM enables direct wafer retrieval of ultrathin serial sections for large-volume electron microscopy

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Randomized trial demonstrates lower costs and ease of use in ultrathin section collection, suggesting broader access for neuroscience.

The aim is to develop a low-cost solution for collecting ultrathin sections for large-volume electron microscopy.
Introduction of DRIFT-EM utilizing static ionizers for section retrieval.
Implementation of a thermoplastic boundary and open-source software for automation.
Comparison of section packing densities with established methods.
Achieved packing densities comparable to magnetic methods with lower costs.
Minimized setup costs and maintenance when using DRIFT-EM.
Facilitated integration with existing volume electron microscopy workflows.

Medina et al. (2026) studied this question.

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