Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 8, 2026Translational OncologyOpen Access

Mitochondrial RNA helicase DDX28 promotes cell cycle and DNA repair programs and shapes an immunosuppressive microenvironment in acute myeloid leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

ZWZi WangYLYunli LiuXGXinzhu Guan

Discussion

Loading...

Member takes

Overview

Randomized trial uncovers DDX28's role in DNA repair and immune suppression in acute myeloid leukemia, suggesting new therapeutic avenues.

Key Points

  • This research aims to evaluate DDX28 as a prognostic biomarker and its role in cell cycle and immune evasion mechanisms in acute myeloid leukemia.
  • Profiled DDX28 expression across AML cohorts using integrated multi-omics resources.
  • Applied functional annotation and pathway analysis to explore the mechanistic role of DDX28.
  • Conducted single-cell RNA-seq to analyze DDX28 distribution in malignant blasts and T cells.
  • High DDX28 expression correlates with inferior survival and increased blast burden.
  • Elevated DDX28 levels are linked to promoter hypomethylation and greater enrichment in cell cycle and DNA repair programs.
  • DDX28 knockdown in HEL cells decreased proliferation and impaired migration and invasion capabilities.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ddcbfa21ec5bbf060d7https://doi.org/10.1016/j.tranon.2026.102766
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DDX27 in cancer: molecular mechanisms, clinical implications, and therapeutic potential2025
  2. 2Granulocyte maturation and splicing defects in DDX41-mutated leukemia2025
  3. 3Pan-cancer analysis and breast cancer validation reveal DEAD-box helicase 23 as a crucial prognostic and immuno-biomarker2026
  4. 4m<sup>6</sup>A‐dependent upregulation of DDX21 by super‐enhancer‐driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia2024 · 22 citations
  5. 5MDS/AML-associated DDX41 helicase facilitates homologous recombination repair by potentially resolving R-loops2026