What question did this study set out to answer?

This analysis investigates the impact of reverse cherry-picking on endovascular treatment outcomes for medium distal vessel occlusion strokes.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1808 Reverse Cherry Picking in Large Randomized Controlled Trials—results From the Distal Trial

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Authors

ASAlexander StebnerUniversity of Calgary VAVera AebischerUniversity of Basel MGMichail Panagiotis GiannakakisUniversity of Bern

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Implication

Retrospective analysis reveals non-randomized patients with MDVO strokes had worse outcomes post-EVT, indicating implications for trial interpretation.

Key Points

This analysis investigates the impact of reverse cherry-picking on endovascular treatment outcomes for medium distal vessel occlusion strokes.
Retrospective analysis of non-randomized patients fulfilling DISTAL trial criteria.
Assessment of baseline characteristics and 90-day functional outcomes using regression analysis.
Analysis of all eligible patients at two centers regardless of treatment strategy.
273 eligible patients treated outside of the trial had higher baseline NIHSS scores (9 vs 6; P<0.001).
Patients outside the trial showed lower 90-day mRS outcomes (cOR 0.68, 95% CI 0.48–0.97) after adjusting for baseline factors.
EVT was preferentially performed on patients with higher NIHSS scores and more proximal occlusions.

Cite This Study

Stebner et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf0647d https://doi.org/10.1093/esj/aakag023.122

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Implication

Retrospective analysis reveals non-randomized patients with MDVO strokes had worse outcomes post-EVT, indicating implications for trial interpretation.

Abstract Number: Esoc2026a1808 Reverse Cherry Picking in Large Randomized Controlled Trials—results From the Distal Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract Number: Esoc2026a1808 Reverse Cherry Picking in Large Randomized Controlled Trials—results From the Distal Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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