What question did this study set out to answer?

The aim is to develop a new method for directly transforming aliphatic amines into reactive alkyl radicals using copper catalysis.

May 8, 2026Organic Letters0 citations

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Direct Deaminative C(sp 3 )–N Cross-Coupling via Copper Catalysis

YYYuqi YangXiangya Hospital Central South University XPXidong PangMinzu University of China YWYi WeiMinzu University of China

Key Points

The aim is to develop a new method for directly transforming aliphatic amines into reactive alkyl radicals using copper catalysis.
Utilized copper catalysis to facilitate the deaminative cross-coupling process.
Conducted reactions under mild conditions.
Explored a broad substrate scope for diverse aliphatic amines.
Successfully generated reactive alkyl radicals.
Achieved the transformation of various aliphatic amines.
Demonstrated a practical application for radical reactions in organic synthesis.

Abstract

generate reactive alkyl radicals. This protocol proceeds under mild reaction conditions and exhibits a broad substrate scope. The success of this reaction provides a novel and practical approach for the direct transformation of aliphatic amines in radical reactions.

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Direct Deaminative C(sp 3 )–N Cross-Coupling via Copper Catalysis

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Abstract

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