Direct Deaminative C(sp ³ )–N Cross-Coupling via Copper Catalysis

Yuqi Yang; Xidong Pang; Yi Wei; Xiao‐Qiang Hu

doi:10.1021/acs.orglett.6c01556

May 5, 2026Organic Letters

Direct Deaminative C(sp ³ )–N Cross-Coupling via Copper Catalysis

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Key Points

The aim is to develop a new method for directly transforming aliphatic amines into reactive alkyl radicals using copper catalysis.
Utilized copper catalysis to facilitate the deaminative cross-coupling process.
Conducted reactions under mild conditions.
Explored a broad substrate scope for diverse aliphatic amines.
Successfully generated reactive alkyl radicals.
Achieved the transformation of various aliphatic amines.
Demonstrated a practical application for radical reactions in organic synthesis.

Abstract

generate reactive alkyl radicals. This protocol proceeds under mild reaction conditions and exhibits a broad substrate scope. The success of this reaction provides a novel and practical approach for the direct transformation of aliphatic amines in radical reactions.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf06626 https://doi.org/10.1021/acs.orglett.6c01556

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Direct Deaminative C(sp ³ )–N Cross-Coupling via Copper Catalysis

Key Points

Abstract

Discussion

Cite This Study

Direct Deaminative C(sp ³ )–N Cross-Coupling via Copper Catalysis

Key Points

Abstract

Discussion

Cite This Study

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