Population
Rabbit aorta (intact arterial smooth muscle cells)
Design
Preclinical
Authors
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Remains preclinical in rabbits; leaves open whether Ca uptake thresholds translate to human vascular tone or disease.
The study demonstrates that high potassium-induced depolarization activates aortic smooth muscle via net calcium uptake, which is modulated by cAMP levels.
C. van Breemen (1977) studied this question.
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