Study of the Anti-Inflammatory Effect of Dipyridamole in Rats Model by Airway Inflammation

Background: Airway inflammation is often caused by pathogens or exposure to pollutants toxins, allergens, and irritants. The lungs are vital organs and excessive inflammation can be life-threatening. Treatment with anti-inflammatory drugs is essential. Objective: This study aims to investigate the anti-inflammatory activity of dipyridamole (DP) to improve inflammatory events associated with airway inflammation. Materials and Methods: A total of 24 healthy male rats were weighting (150–300 g), which are divided into four groups, each group consists of six rats. Group A: rats were administered distilled water orally, which is considered a control group. Group B: rats were administered distilled water orally with sensitization (by ovalbumin), which is considered a positive control group. Group C: rats were administrated (26.4 mg/kg) DP orally with sensitization. Group D: rats were administrated prednisolone (4.12 mg/kg) orally with sensitization. Results: The results revealed that there was a significant reduction ( P < 0.05) of rat serum levels of interleukin (IL)-6 and tumor necrosis factor-alpha for groups C and D when compared with ova-sensitized positive control (group B). Regarding rat serum levels of IL-4 for groups C and D were reduced, but group C was non-significant ( P > 0.05) when compared with ova sensitize positive (group B). In addition, group C was non-significant elevated ( P > 0.05). IL-10 level in rat serum when compared with ova sensitize positive (group B) but group D was significant. Conclusion: This study concludes that DP has an anti-inflammatory effect in the airway sensitization model as it reduces inflammatory cytokines levels in rat serum.