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May 8, 2026Reviews in the NeurosciencesOpen Access

Immune-driven mechanisms in idiopathic intracranial hypertension: a critical synthesis

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Authors

BYBerrak YetimlerETErdem Tüzün

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Overview

Critical synthesis reveals immune contributions to idiopathic intracranial hypertension, suggesting new therapeutic avenues.

Key Points

  • To explore the role of immune mechanisms in the pathophysiology of idiopathic intracranial hypertension (IIH).
  • Reviewed current literature on immune system contributions to IIH and its association with inflammation.
  • Integrated findings related to obesity, cytokine profiles, and neuroglial stress markers.
  • Searched for correlations between IIH and comorbid inflammatory and autoimmune conditions.
  • Identified potential immune-mediated pathways that may influence cerebrospinal fluid dynamics in IIH.
  • Highlighted the presence of pro-inflammatory cytokines that could affect disease progression.
  • Noted the need for further studies to understand mechanistic pathways and therapeutic potential.

Cite This Study

Yetimler et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e79bfa21ec5bbf06b62https://doi.org/10.1515/revneuro-2025-0148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cerebrospinal fluid and serum biomarkers in idiopathic intracranial hypertension: A systematic review.2025 · 5 citations
  2. 2Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications2026
  3. 3Routine Blood and Cerebrospinal Fluid Markers in Newly Diagnosed Idiopathic Intracranial Hypertension: An Exploratory Case–Control Study2026
  4. 4Cognitive impairment in idiopathic intracranial hypertension: A conceptual framework and therapeutic implications2026
  5. 5A multidimensional evaluation of patients with idiopathic intracranial hypertension: associations across symptoms, imaging, cerebrospinal fluid findings and medical history2025