What question did this study set out to answer?

Abstract Number: Esoc2026a153 Efficacy and Safety of Adjunctive Intra-Arterial Thrombolysis Following Endovascular Thrombectomy in Acute Ischemic Stroke: An Updated Meta-Analysis of Randomised Controlled Trials

View Full Paper

Ask AI

Bookmark

Authors

Meta-analysis evaluates effectiveness and safety of intra-arterial thrombolysis in acute ischemic stroke, suggesting benefits in selected subgroups.

To assess the efficacy and safety of adjunctive intra-arterial thrombolysis following endovascular thrombectomy for acute ischemic stroke.
Systematic review of international stroke guidelines and meta-analysis of randomized controlled trials.
Search of PubMed, Embase, and ClinicalTrials.gov for RCTs comparing EVT + IAT with EVT alone.
Primary outcome: 90-day disability-free survival; secondary outcomes included functional independence, mortality, and sICH.
Six RCTs (n=1807) showed IAT improved disability-free survival (OR 1.38; 95% CI: 1.14–1.67).
Greatest benefits seen in females (OR 1.85) and those with anterior circulation occlusion (OR 1.36).
No significant differences in functional independence, mortality, or sICH.

Xia et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Meta-analysis evaluates effectiveness and safety of intra-arterial thrombolysis in acute ischemic stroke, suggesting benefits in selected subgroups.