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Biological sex modulates dynamic cerebral autoregulation and its directional sensitivity | Synapse

May 8, 2026AJP Heart and Circulatory Physiology2 citationsOpen Access

Biological sex modulates dynamic cerebral autoregulation and its directional sensitivity

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LLLawrence LabrecqueInstitut Universitaire de Cardiologie et de Pneumologie de Québec MRMarc‐Antoine RoyInstitut Universitaire de Cardiologie et de Pneumologie de Québec SDShahrzad Soleimani DehnaviInstitut Universitaire de Cardiologie et de Pneumologie de Québec

Key Points

To examine how biological sex impacts dynamic cerebral autoregulation and its directional sensitivity.
Assessed dynamic cerebral autoregulation in males and females during physiological stress.
Measured directional sensitivity at a frequency of ~0.10 Hz OLBNP in participants.
Females demonstrated superior dynamic cerebral autoregulation compared to males.
Females displayed greater directional sensitivity at ~0.10 Hz OLBNP.

Abstract

in females only. These findings indicate that females exhibit better dCA and greater directional sensitivity at 0.10 Hz OLBNP.

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Cite This Study

Labrecque et al. (Wed,) studied this question.

synapsesocial.com/papers/69fd7eb0bfa21ec5bbf06e40 https://doi.org/https://doi.org/10.1152/ajpheart.00641.2025