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May 8, 2026BMC GastroenterologyOpen Access

Circulating miR-184 and miR-206 as predictive biomarkers for early recurrence in HBV-related hepatocellular carcinoma: a prospective study

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Authors

SKS Y KimRLRyunjin LeeETEunyoung Tak

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Overview

Prospective study identifies miR-184 and miR-206 as predictors of early recurrence in HBV-related HCC, suggesting their potential clinical utility.

Key Points

  • This study aims to identify circulating microRNAs that can predict early recurrence in patients with HBV-related hepatocellular carcinoma after curative resection.
  • Prospective enrollment of 30 patients with HBV-related HCC and single tumor (< 5 cm).
  • Blood samples were collected preoperatively and on postoperative day 7 for miRNA expression analysis.
  • Participants were categorized into early recurrence and non-recurrence groups for comparison of miRNA expression.
  • Postoperative day 7 expression of miR-184 and miR-206 was significantly lower in the early recurrence group (p < 0.05).
  • No significant differences were observed in other miRNAs examined.
  • Target gene analysis identified 16 key hub proteins involved in cancer-related pathways associated with HCC progression.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ec6bfa21ec5bbf07108https://doi.org/10.1186/s12876-026-04871-w
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