Downregulation of serum LINC00487 as a biomarker for predicting onset and short-term prognosis in acute coronary syndrome

Objectives long non-coding RNAs (lncRNAs) are critically involved in the pathogenesis of acute coronary syndrome (ACS) and have been linked to major adverse cardiovascular events (MACE). This study was designed to examine the diagnostic precision of LINC00487 in ACS patients and its ability to predict MACE. Methods a cohort of 120 participants was recruited, comprising 75 ACS patients and 45 healthy controls. Serum levels of LINC00487 were quantified via reverse transcription quantitative real-time PCR (RT-qPCR). Predictive utility of LINC00487 for ACS was assessed using receiver operating characteristic (ROC) curves and multivariate logistic regression. Participants were monitored over 6 months to document incident MACE. Correlational analyses were carried out to examine the association between LINC00487 expression and ACS severity. Prognostic relevance of LINC00487 in ACS was evaluated via Kaplan-Meier (K-M) curves. Additionally, multivariate Cox proportional hazards regression was employed to identify predictors of MACE. Results expression of LINC00487 was markedly reduced in ACS patients and demonstrated a negative correlation with cardiac troponin I (cTnI), SYNTAX score, and Gensini score. LINC00487 exhibited high discriminative power between ACS patients and healthy controls (AUC=0.843). Reduced LINC00487 expression was significantly associated with MACE development among ACS subjects (p=0.027). K-M analysis further underscored a pronounced relationship diminished LINC00487 expression and MACE incidence. LINC00487 was established a protective factor against MACE in ACS (HR=0.204, 95 % CI: 0.083–0.500, p=0.001). Conclusions serum LINC00487 expression is associated with ACS severity, and its downregulation has diagnostic and prognostic value for ACS.