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May 8, 2026MetabolitesOpen Access

Targeting the Gut–Brain Axis: Protective Effects of NMN in Alleviating D-Galactose-Induced Cognitive Deficits

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Authors

ZZZhenyang ZangWenzhou Medical UniversityFCFeng ChenWenzhou Medical UniversityQTQiulian TangWenzhou Medical University

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Overview

Randomized trial evaluates NMN's impact on cognitive decline in aging mice, suggesting neuroprotective strategies.

Key Points

  • This research investigates the potential neuroprotective effects of NMN in a mouse model of cognitive decline induced by D-galactose.
  • Mice received subcutaneous D-galactose and oral NMN (300 or 500 mg/kg) for six weeks.
  • Cognitive function was assessed through the Y-maze and Elevated Plus Maze tests.
  • Analyses included ELISA, Western blotting, and 16S rRNA sequencing for oxidative stress and gut microbiota.
  • NMN improved spatial memory (p<0.05) without affecting anxiety levels.
  • Increased antioxidant enzyme activities (SOD, GSH, CAT) and decreased malondialdehyde and pro-inflammatory cytokines were observed.
  • Enhanced butyrate-producing gut microbiota and activation of the Nrf2/HO-1 pathway were noted.

Cite This Study

Zang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ee0bfa21ec5bbf072c6https://doi.org/10.3390/metabo16050314
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