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This research aims to assess trends in case-fatality, long-term survival, and recurrence rates after stroke in young and middle-aged individuals.

Abstract Number: Esoc2026a197 Temporal Trends in Case-Fatality, Long-Term Survival and Recurrence After Stroke in Young and Middle-Aged Individuals: A Systematic Review and Meta-Analysis

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This research aims to assess trends in case-fatality, long-term survival, and recurrence rates after stroke in young and middle-aged individuals.
Systematic review and meta-analysis of studies from Embase and Medline published between 1970 and 2024.
Included studies reported on case-fatality and stroke recurrence in individuals aged ≤65 years.
Risk ratios pooled using inverse-variance random-effects models and annualized changes estimated using meta-regression.
Case-fatality has decreased with a relative risk (RR) of 0.74 (95% CI: 0.68–0.81; I2=0.92), averaging a decline of 3.2% per year.
Trends in case-fatality were consistent across age, sex, and regions, showing ongoing improvements since 2010.
Stroke recurrence rates have remained unchanged post-2000, with a one-year cumulative risk of 1.04 (0.78–1.39; p=0.69) after ischaemic stroke.

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Systematic review shows improved case-fatality but stagnant stroke recurrence rates in young adults, indicating areas for further study.

Nehme et al. (2026) studied this question.

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