Abstract Number: Esoc2026a941 Mechanisms of End in Minor Stroke With Large Vessel Occlusion Based on Cerebrovascular Reactivity Mapping Using Resting-State Bold Fmri
Randomized trial investigates hemodynamic mechanisms of early neurological deterioration in minor stroke patients, suggesting reduced blood flow reserves.
Key Points
The study aimed to understand the hemodynamic mechanisms causing early neurological deterioration in minor stroke patients with large vessel occlusion.
Single-center prospective study
Included acute ischemic stroke patients with NIHSS≤5 and anterior circulation LVO or severe stenosis
Measured cerebrovascular reactivity using resting-state BOLD fMRI before END
14.9% of patients experienced early neurological deterioration
Patients with END had significantly lower rCVRMCA (0.25 vs. 0.84) and other rCVR metrics (p<0.001)
rCVRMCA demonstrated the highest predictive performance for END with AUC = 0.93