PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 8, 2026BMJ Open0 citationsOpen Access

Prospective longitudinal study of respiratory syncytial virus and other respiratory viruses in children <5 years in community settings in metropolitan western Australia: the PATROL study

View Full Paper
AWAnita WilliamsThe Kids Research Institute AustraliaJHJoanne HarveyPrincess Margaret Hospital for ChildrenEBE BastianPathwest Laboratory Medicine

Key Points

  • This study aims to understand the community burden of respiratory syncytial virus (RSV) in children under 5 years old.
  • Prospective longitudinal observational study conducted in community settings in Perth, Western Australia.
  • Parents/guardians collected mid-nasal swabs for testing at four points aligned with RSV season.
  • Swabs tested for RSV and other respiratory viruses using PCR and rapid antigen tests.
  • Incidence rates of RSV illness and asymptomatic carriage will be calculated.
  • Comparison of incidence rates of RSV with other respiratory viruses is planned.

Abstract

Introduction Respiratory syncytial virus (RSV) is a significant cause of respiratory infections in young children. Since 2021, RSV has been a notifiable disease in Australia. However, current surveillance systems focus on hospitalised RSV, with limited surveillance at a community level through primary care clinics. This approach only captures RSV requiring hospitalisation. Less severe illnesses, while not captured, may have significant social and economic impacts including the associated cost of care and absenteeism. The aim of this study is to establish an understanding of the broader burden of RSV in young children in a community setting. Methods and analysis The PATROL (Parents Actively Tracking RSV in Little Ones) project is a prospective longitudinal observational study of RSV and other respiratory viruses in children <5 years in community settings in metropolitan Perth, Western Australia. Over a 12-month surveillance period, parent/guardians will collect a mid-nasal swab from their child any time they meet the case definition or during one of the four screening points aligned with key points in the RSV season. Swabs will be tested for RSV and other respiratory viruses by PCR, with results returned to the parent/guardian. Rapid antigen tests for RSV, SARS-CoV-2 and Influenza A/B are provided for at-home testing in addition to PCR. Symptoms are reported by parents/guardians using MyCap, a phone-based application for REDCap. Incidence rates of RSV illness and asymptomatic carriage will be calculated and compared with the incidence rate ratios of other respiratory viruses. Ethics and dissemination The Government of Western Australia Child and Adolescent Health Service Human Research Ethics Committee approved all study materials. Results and findings will be disseminated through manuscripts, conference abstracts and presentations, participant newsletters and appropriate general news media items.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Williams et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ef7bfa21ec5bbf075a6https://doi.org/10.1136/bmjopen-2025-114122
Ask AI
Helpful
Bookmark
Share
View Full Paper