First‐Line Antiarrhythmic Transplacental Treatment for Fetal Tachyarrhythmia: A Systematic Review and Meta‐Analysis
Why the study?
Does flecainide improve efficacy compared to digoxin in fetuses with fetal supraventricular tachycardia?
Population
Fetuses with fetal tachyarrhythmia (specifically fetal supraventricular tachycardia and atrial flutter)
Comparison
Flecainide as first-line monotherapy vs Digoxin as first-line monotherapy
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
May support flecainide over digoxin as first-line for fetal SVT; extends meta-analytic evidence in this rare condition.
Structured PICO
Does flecainide improve efficacy compared to digoxin in fetuses with fetal supraventricular tachycardia?
P
Population
Fetuses with fetal tachyarrhythmia (specifically fetal supraventricular tachycardia and atrial flutter)
I
Intervention
Flecainide as first-line monotherapy
C
Comparator
Digoxin as first-line monotherapy
O
Outcome
Efficacy, safety, and fetal-maternal tolerance
Flecainide may be a more effective first-line treatment than digoxin for fetal supraventricular tachycardia.
Cite This Study
Alsaied et al. (2017) studied this question.