What question did this study set out to answer?

This study aims to investigate the cognitive effects of dexamphetamine and zolpidem in healthy men.

May 8, 2026Fundamental and Clinical PharmacologyOpen Access

Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men

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Authors

VPVeronika Pfoser-PoschacherKlinik Hietzing MWMichael WolfUniversity of Vienna MBMichaela Bayerle‐EderMedical University of Vienna

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Implication

Randomized trial investigates cognitive effects of dexamphetamine and zolpidem in healthy men, suggesting varied impacts on attention and reaction time.

Key Points

This study aims to investigate the cognitive effects of dexamphetamine and zolpidem in healthy men.
Randomized, double-blind, placebo-controlled trial
60 healthy men aged 26 ± 5 years received 30-mg dexamphetamine, 5-mg zolpidem, or placebo
Cognitive performance assessed using Psytest system at baseline, 3 h, and 8 h after dosing.
At 8 hours, both dexamphetamine and zolpidem improved sustained attention, with significant reduction in omissions.
Zolpidem showed impaired phasic alertness, whereas working memory remained unchanged.
No correlation between plasma concentrations of the drugs and cognitive performance was found.

Cite This Study

Pfoser-Poschacher et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f3abfa21ec5bbf07a31 https://doi.org/10.1111/fcp.70092

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Implication

Randomized trial investigates cognitive effects of dexamphetamine and zolpidem in healthy men, suggesting varied impacts on attention and reaction time.

Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men

Discussion

Member takes

Implication

Key Points

Cite This Study

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