Case reports highlight morphologic diversity and suggest aggressive behavior in NF2-mutated renal cell carcinoma, indicating the need for integrated diagnostic approaches.
-mutated RCC and underscore the necessity of an integrated diagnostic approach combining histology, immunohistochemistry (especially merlin loss), and molecular confirmation. Recognizing this entity is critical for accurate classification and for guiding potential therapeutic strategies, including immune checkpoint inhibitors.
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Zhao et al. (2026) studied this question.
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