Network pharmacology demonstrates oleuropein's inhibition of urease in Helicobacter pylori, suggesting potential therapeutic benefits.
Oleuropein inhibited the activity of H. pylori urease in a time-dependent, mixed-type and reversible manner. Mechanistic analyses suggested that the inhibition was associated with thiol groups on urease and may involve the flap residue CYS321.
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Zhao et al. (2026) studied this question.
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