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May 8, 2026Annals of Surgical OncologyOpen Access

The Full Scope: Standardization of the Use of Endoscopy for Earlier Diagnosis of Stomach Cancer in the USA

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Authors

GSGregory SiglerBWBrittany WalkerJWJennifer Weiss

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Overview

Randomized trial examines diagnosis of stomach cancer in patients, indicating need for standardized endoscopy protocols.

Key Points

  • The research aims to analyze the standardization of diagnostic endoscopy in detecting gastric cancer earlier in the USA.
  • Analyzed 249 patients with gastric or gastroesophageal junction adenocarcinoma over 10 years.
  • Assessed demographics, symptoms, diagnostic evaluations, stage at diagnosis, and outcomes.
  • Evaluated overall survival rates based on diagnostic methods.
  • Median overall survival for all patients was 23.0 months (95% CI 14.4–31.6).
  • Stage I patients had not reached median overall survival, stage II had 47.0 months (95% CI 24.3–69.7), stage III had 23.0 months (95% CI 19.9–26.3), and stage IV had 11.0 months (95% CI 6.6–15.4) (p < 0.001).
  • Initial diagnosis via non-EGD methods predicted poorer survival (HR 1.46, 95% CI 1.03–2.09; p = 0.036).

Cite This Study

Sigler et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f86bfa21ec5bbf08175https://doi.org/10.1245/s10434-026-19765-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4794: Impact of prior upper endoscopy on gastric cancer stage and survival2024
  2. 2Patterns of upper endoscopy use prior to gastric cancer diagnosis among high-risk populations.2026
  3. 3Impact of Prior Upper Endoscopy on Gastric Cancer Stage and Survival in Older Adults2025 · 2 citations
  4. 4Association between pre-diagnostic upper endoscopy and metastatic gastric cancer at diagnosis among patients from high-risk groups.2026
  5. 5Pilot study of stomach cancer early detection and prevention with endoscopy (Pilot-SCREEN): Acceptability and feasibility results.2026