Is pulse pressure a mediator in the relationship between hyperoxemia and acute brain injury in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients? An ELSO registry study

and PP were inversely related. In mediation analysis PP accounted for 8.2% of the total effect of hyperoxemia on ABI overall (14% in the non-LV-vented cohort).ConclusionSevere hyperoxemia during ECMO was associated with increased ABI risk. Low PP was not. PP mediated the relationship between hyperoxemia and ABI. Reduced cardiac function may drive proximal dual circulation shift, predisposing patients to hyperoxemia and ABI. Hyperoxemia appears modifiable, and improved PP may reduce ABI.